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Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice
The functional impact of most genomic alterations found in cancer, alone or in combination, remains largely unknown. Here we integrate tumor barcoding, CRISPR/Cas9-mediated genome editing and ultra-deep barcode sequencing to interrogate pairwise combinations of tumor suppressor alterations in autochthonous mouse models of human lung adenocarcinoma. We map the tumor suppressive effects of 31 common lung adenocarcinoma genotypes and identify a landscape of context dependence and differential effect strengths.
pmid: 29610476 Nat Genet 影響因子: 25.455 發表日期: 20180401 官網 免費下載 全文下載
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